He was ordained a monk on July 31, 1988, and after a year he was ordained a priest on December 23, 1989. Two months after, H.H. Pope Tawadros started serving with H.E. Metropolitan Pakhomious of Beheira on February 15, 1990. He was ordained a bishop on June 15, 1997, by H.H. the Late Pope Shenouda III as a General Bishop assisting H.E. Metropolitan Pakhomious. His Holiness focused on childhood whether it was in the country-wide children’s festival as well when he was in charge of the children’s committee in the Holy Synod. Before assuming the papacy, H.H. wrote twelve books.
His Holiness was enthroned as the 118th Pope of Alexandria and Pope of the See of St. Mark on November 18, 2012, at the Cathedral of St. Reweis in Abbassiya, Cairo. The enthronement was presided by H.E. Metropolitan Pakhomious of Beheira, other metropolitans, and bishops of the Coptic church and was attended by many delegates of Christian Churches